InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARRB2

Summary

InnateDB Gene

IDBG-19263.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARRB2

Gene Name

arrestin, beta 2

Synonyms

ARB2; ARR2; BARR2

Species

Homo sapiens

Ensembl Gene

ENSG00000141480

Encoded Proteins

IDBP-19265

arrestin, beta 2

IDBP-19267

arrestin, beta 2

IDBP-19269

arrestin, beta 2

IDBP-362711

arrestin, beta 2

IDBP-759062

IDBP-760925

IDBP-763121

IDBP-764327

IDBP-763513

IDBP-761283

IDBP-764000

IDBP-759530

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19783052

ARRB2 acts to limit JNK/ERK activation and survival in macrophages and is required for basal and TLR-inducible complement C1q expression.

PMID 20497256

ARRB2 regulates TLR4-mediated apoptotic signalling through GSK3B where ARRB2 represents an inhibitory effect on the TLR4-mediated apoptotic cascade, through controlling the homeostasis of activation and inactivation of GSK3B.

Entrez Gene

Summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:4710489-4721499

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000381488	ENSP00000370898
ENST00000269260	ENSP00000269260
ENST00000346341	ENSP00000341895
ENST00000412477	ENSP00000403701
ENST00000575131
ENST00000572497	ENSP00000458946
ENST00000574888
ENST00000571428	ENSP00000465877
ENST00000575877	ENSP00000466857
ENST00000571791
ENST00000574954	ENSP00000466344
ENST00000577054
ENST00000574502	ENSP00000458371
ENST00000572457	ENSP00000465296
ENST00000571206	ENSP00000460607
ENST00000570718
ENST00000576235	ENSP00000460879
ENST00000573886
ENST00000570739
ENST00000572782

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 388 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	388 [view]
Protein-Protein	386 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding
GO:0031691	alpha-1A adrenergic receptor binding
GO:0031692	alpha-1B adrenergic receptor binding
GO:0031701	angiotensin receptor binding
GO:0031702	type 1 angiotensin receptor binding
GO:0031748	D1 dopamine receptor binding
GO:0031762	follicle-stimulating hormone receptor binding
GO:0031826	type 2A serotonin receptor binding
GO:0032403	protein complex binding
GO:0032947	protein complex scaffold
GO:0043422	protein kinase B binding
GO:0051019	mitogen-activated protein kinase binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0002031	G-protein coupled receptor internalization
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092	positive regulation of receptor internalization
GO:0006366	transcription from RNA polymerase II promoter
GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007420	brain development
GO:0007596	blood coagulation
GO:0007628	adult walking behavior
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0030168	platelet activation
GO:0031397	negative regulation of protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0031623	receptor internalization
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032226	positive regulation of synaptic transmission, dopaminergic
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032695	negative regulation of interleukin-12 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0034260	negative regulation of GTPase activity
GO:0034392	negative regulation of smooth muscle cell apoptotic process
GO:0042699	follicle-stimulating hormone signaling pathway
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965	detection of temperature stimulus involved in sensory perception of pain
GO:0051897	positive regulation of protein kinase B signaling
GO:0051928	positive regulation of calcium ion transport
GO:0060326	cell chemotaxis
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:2000573	positive regulation of DNA biosynthetic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0014069	postsynaptic density
GO:0016323	basolateral plasma membrane
GO:0030139	endocytic vesicle
GO:0031410	cytoplasmic vesicle
GO:0043197	dendritic spine
GO:0045211	postsynaptic membrane