Version 5.4
Homo sapiens Gene: RAF1
Summary
InnateDB Gene IDBG-19277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAF1
Gene Name v-raf-1 murine leukemia viral oncogene homolog 1
Synonyms c-Raf; CMD1NN; CRAF; NS5; Raf-1
Species Homo sapiens
Ensembl Gene ENSG00000132155
Encoded Proteins
IDBP-19279
v-raf-1 murine leukemia viral oncogene homolog 1
IDBP-364474
v-raf-1 murine leukemia viral oncogene homolog 1
IDBP-364508
v-raf-1 murine leukemia viral oncogene homolog 1
IDBP-364519
v-raf-1 murine leukemia viral oncogene homolog 1
IDBP-364520
v-raf-1 murine leukemia viral oncogene homolog 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:12583601-12664226
Strand Reverse strand
Band p25.2
Transcripts
ENST00000251849 ENSP00000251849
ENST00000442415 ENSP00000401888
ENST00000432427 ENSP00000398591
ENST00000423275 ENSP00000401088
ENST00000416093 ENSP00000391265
ENST00000471449
ENST00000465826
ENST00000475353
ENST00000494557
ENST00000460610
ENST00000491290
ENST00000492690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 252 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 252 [view]
Protein-Protein 252 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017016 Ras GTPase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0001666 response to hypoxia
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0031333 negative regulation of protein complex assembly
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034220 ion transmembrane transport
GO:0035019 somatic stem cell maintenance
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response
GO:0045104 intermediate filament cytoskeleton organization
GO:0045595 regulation of cell differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0071550 death-inducing signaling complex assembly
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000145 regulation of cell motility
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031143 pseudopodium
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000000441
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_5
ID pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_17
IL5 pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_2077
RAF activation pathway
REACT_614
RAF phosphorylates MEK pathway
REACT_962
MEK activation pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_23898
Rap1 signalling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_160189
Stimuli-sensing channels pathway
REACT_23847
GP1b-IX-V activation signalling pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_12033
Signalling to RAS pathway
REACT_524
SOS-mediated signalling pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_9417
Signaling by EGFR pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_661
SHC-mediated signalling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_999
SHC-related events pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_13685
Neuronal System pathway
REACT_12529
Signaling by VEGF pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_634
RAF/MAP kinase cascade pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_25300
Ion channel transport pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_116125
Disease pathway
REACT_169118
Signaling by Leptin pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04912
GnRH signaling pathway pathway
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04540
Gap junction pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa04720
Long-term potentiation pathway
hsa05219
Bladder cancer pathway
hsa05214
Glioma pathway
hsa04910
Insulin signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04730
Long-term depression pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04916
Melanogenesis pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
B cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
NGF signaling pathway pathway
INOH website
IGF1 signaling pathway pathway
INOH website
GPCR signaling pathway
INOH website
PDGF signaling pathway pathway
PID NCI
ar_nongenomic_pathway
Nongenotropic Androgen signaling
ceramide_pathway
Ceramide signaling pathway
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
rb_1pathway
Regulation of retinoblastoma protein
il2_1pathway
IL2-mediated signaling events
erbb1_internalization_pathway
Internalization of ErbB1
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
erbb1_downstream_pathway
ErbB1 downstream signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
igf1_pathway
IGF1 pathway
endothelinpathway
Endothelins
bcr_5pathway
BCR signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
tcrraspathway
Ras signaling in the CD4+ TCR pathway
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
shp2_pathway
SHP2 signaling
gmcsf_pathway
GMCSF-mediated signaling events
cxcr3pathway
CXCR3-mediated signaling events
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632896
RefSeq NM_002880 XM_005265355 XM_005265360
HUGO
OMIM
CCDS CCDS2612
HPRD 01265
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca