Version 5.4
Mus musculus Gene: Rag1
Summary
InnateDB Gene IDBG-193190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rag1
Gene Name recombination activating gene 1
Synonyms Rag-1
Species Mus musculus
Ensembl Gene ENSMUSG00000061311
Encoded Proteins
IDBP-193192
recombination activating gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21746813
Rag1 knockout mice display deficient early inflammatory responses and reduced survival during sepsis, which demonstrates a novel role of B cells in the early innate immune response.
InnateDB Annotation from Orthologs
Summary
PMID 21746813
[Homo sapiens] Rag1 knockout mice display deficient early inflammatory responses and reduced survival during sepsis, which demonstrates a novel role of B cells in the early innate immune response. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166349:
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:101638282-101649501
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000078494 ENSMUSP00000077584
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 19 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016881 acid-amino acid ligase activity
GO:0042393 histone binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0002250 adaptive immune response
GO:0002331 pre-B cell allelic exclusion
GO:0006310 DNA recombination
GO:0010390 histone monoubiquitination
GO:0016265 death
GO:0030183 B cell differentiation
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0043029 T cell homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045580 regulation of T cell differentiation
GO:0048538 thymus development
GO:0051865 protein autoubiquitination
GO:0070233 negative regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166349
View Gene Order
ENSBTAG00000040293
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05340
Primary immunodeficiency pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05340
Primary immunodeficiency pathway
INOH
PID NCI
Cross-References
SwissProt P15919
TrEMBL Q6XC89 Q8C2F3 Q8C2U3 Q99NN8
UniProt Splice Variant
Entrez Gene 19373
UniGene Mm.828
RefSeq NM_009019 XM_006499012
OMIM
CCDS CCDS16463
HPRD
IMGT
MGI ID MGI:97848
MGI Symbol Rag1
EMBL AK087946 AK088725 AL929569 AY011883 AY241462 BC138342 CH466519 M29475
GenPept AAA40028 AAG38401 AAI38343 AAP76401 BAC40054 BAC40529 CAM20888 EDL27655
RNA Seq Atlas 19373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca