Version 5.4
Mus musculus Gene: Sppl3
Summary
InnateDB Gene IDBG-193230.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sppl3
Gene Name signal peptide peptidase 3
Synonyms 4833416I09Rik; Psl4; Usmg3
Species Mus musculus
Ensembl Gene ENSMUSG00000029550
Encoded Proteins
IDBP-193232
signal peptide peptidase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26851218
Sppl3 is an intramembrane aspartyl protease that controls natural killer cell maturation and cytotoxicity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157837:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:115011137-115098790
Strand Forward strand
Band F
Transcripts
ENSMUST00000031530 ENSMUSP00000031530
ENSMUST00000150708
ENSMUST00000128590
ENSMUST00000128678
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
GO:0042803 protein homodimerization activity
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005791 rough endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000157837
View Gene Order
ENSBTAG00000016338
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.355894 Mm.474662
RefSeq NM_029012 XM_006530474
OMIM
CCDS CCDS19578
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca