Version 5.4
Mus musculus Gene: Asgr1
Summary
InnateDB Gene IDBG-193435.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asgr1
Gene Name asialoglycoprotein receptor 1
Synonyms ASGPR1; Asgr; Asgr-1; HL-1
Species Mus musculus
Ensembl Gene ENSMUSG00000020884
Encoded Proteins
IDBP-193437
asialoglycoprotein receptor 1
IDBP-193439
asialoglycoprotein receptor 1
IDBP-264221
asialoglycoprotein receptor 1
IDBP-540653
asialoglycoprotein receptor 1
IDBP-718363
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141505:
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70054085-70057894
Strand Forward strand
Band B3
Transcripts
ENSMUST00000018699 ENSMUSP00000018699
ENSMUST00000092959 ENSMUSP00000090637
ENSMUST00000108585 ENSMUSP00000104226
ENSMUST00000146411 ENSMUSP00000121842
ENSMUST00000123369 ENSMUSP00000137469
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004873 asialoglycoprotein receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0031668 cellular response to extracellular stimulus
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141505
View Gene Order
ENSBTAG00000012071
Not yet available
Cross-References
SwissProt
TrEMBL J3QPT6
UniProt Splice Variant
Entrez Gene 11889
UniGene
RefSeq NM_001291131 NM_001291132 NM_009714 XM_006532047
OMIM
CCDS CCDS24933 CCDS70224
HPRD
IMGT
MGI ID MGI:88081
MGI Symbol Asgr1
EMBL AL596185
GenPept
RNA Seq Atlas 11889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca