Version 5.4
Mus musculus Gene: Mfge8
Summary
InnateDB Gene IDBG-193646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mfge8
Gene Name milk fat globule-EGF factor 8 protein
Synonyms AA408458; AI325141; lactadherin; MFG-E8; Mfgm; MP47; P47; SED1
Species Mus musculus
Ensembl Gene ENSMUSG00000030605
Encoded Proteins
IDBP-193648
milk fat globule-EGF factor 8 protein
IDBP-266729
milk fat globule-EGF factor 8 protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23454767
MFGE8 inhibits inflammasome-induced IL1B production in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140545:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:79133769-79149060
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000032825 ENSMUSP00000032825
ENSMUST00000107409 ENSMUSP00000103032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008429 phosphatidylethanolamine binding
Biological Process
GO:0001525 angiogenesis
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0007155 cell adhesion
GO:0007338 single fertilization
GO:0045087 innate immune response (InnateDB)
GO:0050766 positive regulation of phagocytosis
GO:2000427 positive regulation of apoptotic cell clearance
Cellular Component
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140545
View Gene Order
ENSBTAG00000003300
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_198563
Amyloids pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75925
Amyloids pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt P21956
TrEMBL Q9QWQ1
UniProt Splice Variant
Entrez Gene 17304
UniGene Mm.1451
RefSeq NM_008594 NM_001045489
OMIM
CCDS CCDS21379 CCDS39989
HPRD
IMGT
MGI ID MGI:102768
MGI Symbol Mfge8
EMBL AB021130 AB021648 AB025280 AK089211 AK152088 AK171143 BC003892 BC003904 M38337 Y11684
GenPept AAA39534 AAH03892 AAH03904 BAA35180 BAA36214 BAA76386 BAC40794 BAE30938 BAE42274 CAA72380
RNA Seq Atlas 17304

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca