InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kars

Summary

InnateDB Gene

IDBG-193865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kars

Gene Name

lysyl-tRNA synthetase

Synonyms

AA589550; AL024334; AL033315; AL033367; D8Ertd698e; D8Wsu108e; LysRS; mKIAA0070

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031948

Encoded Proteins

IDBP-193867

lysyl-tRNA synthetase

IDBP-193869

lysyl-tRNA synthetase

IDBP-622825

lysyl-tRNA synthetase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065427:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:111993440-112011323

Strand

Reverse strand

Band

Transcripts

ENSMUST00000034426	ENSMUSP00000034426
ENSMUST00000093120	ENSMUSP00000090808
ENSMUST00000164470	ENSMUSP00000126268

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004824	lysine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016597	amino acid binding
GO:0046872	metal ion binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006430	lysyl-tRNA aminoacylation
GO:0015966	diadenosine tetraphosphate biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0015630	microtubule cytoskeleton
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000065427

View Gene Order

ENSBTAG00000015677

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00970

Aminoacyl-tRNA biosynthesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15302

Mitochondrial tRNA aminoacylation pathway

REACT_15306

Cytosolic tRNA aminoacylation pathway

REACT_15482

tRNA Aminoacylation pathway

REACT_71

Gene Expression pathway

KEGG

hsa00970

Aminoacyl-tRNA biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q8CFK5 Q8R2P8

UniProt Splice Variant

Entrez Gene

85305

UniGene

Mm.196544 Mm.415281

RefSeq

NM_001286384 XM_006531519 NM_001130868 NM_053092 XM_006544333

OMIM

CCDS

CCDS52677 CCDS40481

HPRD

IMGT

MGI ID

MGI:1934754

MGI Symbol

Kars

EMBL

AC114648 BC027356 BC035324 CH466525

GenPept

AAH27356 AAH35324 EDL11524

RNA Seq Atlas

102641648 85305