Mus musculus Gene: Pxn | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-193898.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | Pxn | ||||||||||||||||||||||||||
Gene Name | paxillin | ||||||||||||||||||||||||||
Synonyms | AW108311; AW123232; Pax | ||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000029528 | ||||||||||||||||||||||||||
Encoded Proteins |
paxillin
paxillin
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089159:
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 5:115506676-115555987 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | F | ||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 172 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Disease pathway
Signaling by VEGF pathway
Smooth Muscle Contraction pathway
Muscle contraction pathway
Signaling by EGFR pathway
VEGFA-VEGFR2 Pathway pathway
Cell-extracellular matrix interactions pathway
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
GAB1 signalosome pathway
Signal Transduction pathway
Cell junction organization pathway
Cell-Cell communication pathway
Signaling by EGFR in Cancer pathway
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
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KEGG |
VEGF signaling pathway pathway
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
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INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TCR pathway
IL3 pathway
IL6 pathway
Prolactin pathway
Oncostatin_M pathway
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REACTOME |
GAB1 signalosome pathway
Signaling by EGFR pathway
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
Localization of the PINCH-ILK-PARVIN complex to focal adhesions pathway
Cell-extracellular matrix interactions pathway
Smooth Muscle Contraction pathway
Signaling by EGFR in Cancer pathway
Cell-Cell communication pathway
Cell junction organization pathway
Signaling by VEGF pathway
Signal Transduction pathway
VEGFA-VEGFR2 Pathway pathway
Muscle contraction pathway
Disease pathway
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KEGG |
Regulation of actin cytoskeleton pathway
VEGF signaling pathway pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
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INOH |
Integrin signaling pathway pathway
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PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
LPA receptor mediated events
CXCR4-mediated signaling events
Integrins in angiogenesis
Alpha9 beta1 integrin signaling events
Signaling events mediated by focal adhesion kinase
IGF1 pathway
Integrin-linked kinase signaling
EPHB forward signaling
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
Fc-epsilon receptor I signaling in mast cells
a4b7 Integrin signaling
Arf6 signaling events
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||
RefSeq | NM_011223 NM_133915 | ||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS19593 CCDS39229 | ||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||