InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Alox15

Summary

InnateDB Gene

IDBG-194131.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alox15

Gene Name

arachidonate 15-lipoxygenase

Synonyms

12-LO; 12/15-LO; 15-LOX; Alox12l; L-12LO

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018924

Encoded Proteins

IDBP-194133

arachidonate 15-lipoxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161905:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:70344152-70352031

Strand

Reverse strand

Band

Transcripts

ENSMUST00000019068	ENSMUSP00000019068
ENSMUST00000130000

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004052	arachidonate 12-lipoxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding
GO:0047977	hepoxilin-epoxide hydrolase activity
GO:0050473	arachidonate 15-lipoxygenase activity
GO:0051120	hepoxilin A3 synthase activity

Biological Process

GO:0001503	ossification
GO:0002820	negative regulation of adaptive immune response
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0010811	positive regulation of cell-substrate adhesion
GO:0019369	arachidonic acid metabolic process
GO:0019372	lipoxygenase pathway
GO:0030282	bone mineralization
GO:0030838	positive regulation of actin filament polymerization
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0034976	response to endoplasmic reticulum stress
GO:0035358	regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035963	cellular response to interleukin-13
GO:0042060	wound healing
GO:0043277	apoptotic cell clearance
GO:0051122	hepoxilin biosynthetic process
GO:0055114	oxidation-reduction process
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071277	cellular response to calcium ion
GO:1901074	regulation of engulfment of apoptotic cell
GO:2001303	lipoxin A4 biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane