Version 5.4
Mus musculus Gene: Kif7
Summary
InnateDB Gene IDBG-194164.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kif7
Gene Name kinesin family member 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000050382
Encoded Proteins
IDBP-194166
kinesin family member 7
IDBP-722782
IDBP-789382
kinesin family member 7
IDBP-789384
kinesin family member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166813:
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:79698098-79715720
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000059836 ENSMUSP00000061806
ENSMUST00000178048 ENSMUSP00000136993
ENSMUST00000183846 ENSMUSP00000139359
ENSMUST00000184137 ENSMUSP00000139224
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
Cellular Component
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005929 cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166813
View Gene Order
ENSBTAG00000002440
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.101633
RefSeq NM_001291222 NM_010626 XM_006540664 XM_006540665 XM_006540666 XM_006540667 XM_006540668 XM_006540669 XM_006540670
OMIM
CCDS CCDS52278
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca