InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Os9

Summary

InnateDB Gene

IDBG-194187.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Os9

Gene Name

amplified in osteosarcoma

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040462

Encoded Proteins

IDBP-194189

amplified in osteosarcoma

IDBP-620451

amplified in osteosarcoma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135506:
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:127094259-127121160

Strand

Reverse strand

Band

Transcripts

ENSMUST00000080975	ENSMUSP00000079770
ENSMUST00000164259	ENSMUSP00000128914

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0002020	protease binding
GO:0005515	protein binding

Biological Process

GO:0006605	protein targeting
GO:0006621	protein retention in ER lumen
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0034976	response to endoplasmic reticulum stress
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process