Version 5.4
Mus musculus Gene: Smpdl3b
Summary
InnateDB Gene IDBG-194305.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smpdl3b
Gene Name sphingomyelin phosphodiesterase, acid-like 3B
Synonyms 1110054A24Rik; Asml3b; AU045240
Species Mus musculus
Ensembl Gene ENSMUSG00000028885
Encoded Proteins
IDBP-194307
sphingomyelin phosphodiesterase, acid-like 3B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26095358
The membrane-modulating enzyme SMPDL3B is a negative regulator of TLR signalling that functions at the interface of membrane biology and innate immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130768:
Gene Information
Type Protein coding
Genomic Location Chromosome 4:132732966-132757252
Strand Reverse strand
Band D2.3
Transcripts
ENSMUST00000030709 ENSMUSP00000030709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006685 sphingomyelin catabolic process
GO:0008150 biological_process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000130768
View Gene Order
ENSBTAG00000012997
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.287187
RefSeq NM_133888
OMIM
CCDS CCDS18733
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca