InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hadh

Summary

InnateDB Gene

IDBG-194385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hadh

Gene Name

hydroxyacyl-Coenzyme A dehydrogenase

Synonyms

AA409008; AU019341; AW742602; Hadhsc; HCDH; Schad

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027984

Encoded Proteins

IDBP-194387

hydroxyacyl-Coenzyme A dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138796:
This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:131233419-131272101

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029610	ENSMUSP00000029610
ENSMUST00000152427

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050660	flavin adenine dinucleotide binding
GO:0051287	NAD binding
GO:0070403	NAD+ binding

Biological Process

GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0009725	response to hormone
GO:0014823	response to activity
GO:0032868	response to insulin
GO:0042493	response to drug
GO:0046168	glycerol-3-phosphate catabolic process
GO:0046676	negative regulation of insulin secretion
GO:0055114	oxidation-reduction process