Version 5.4
| Mus musculus Gene: Prkab1 | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-194478.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Prkab1 | ||||||||||||||||||||||
| Gene Name | protein kinase, AMP-activated, beta 1 non-catalytic subunit | ||||||||||||||||||||||
| Synonyms | 1300015D22Rik; AU021155; E430008F22 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000029513 | ||||||||||||||||||||||
| Encoded Proteins |
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, beta 1 non-catalytic subunit
|
||||||||||||||||||||||
| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111725:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 5:116013586-116024508 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | F | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 158 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Regulation of AMPK activity via LKB1 pathway
Signaling by Insulin receptor pathway
Membrane Trafficking pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Regulation of Rheb GTPase activity by AMPK pathway
PI3K Cascade pathway
IRS-related events pathway
IRS-mediated signalling pathway
Signal Transduction pathway
mTOR signalling pathway
PKB-mediated events pathway
Translocation of GLUT4 to the plasma membrane pathway
|
||||||||||||||||||||||
| KEGG |
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Circadian rhythm pathway
Hypertrophic cardiomyopathy (HCM) pathway
|
||||||||||||||||||||||
| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
|
||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
Leptin pathway
|
||||||||||||||||||||||
| REACTOME |
Regulation of Rheb GTPase activity by AMPK pathway
Regulation of AMPK activity via LKB1 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Translocation of GLUT4 to the plasma membrane pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Organelle biogenesis and maintenance pathway
PKB-mediated events pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
Mitochondrial biogenesis pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Membrane Trafficking pathway
Insulin receptor signalling cascade pathway
PKB-mediated events pathway
IRS-related events triggered by IGF1R pathway
Regulation of Rheb GTPase activity by AMPK pathway
mTOR signalling pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
IRS-related events pathway
Translocation of GLUT4 to the plasma membrane pathway
IRS-mediated signalling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
IGF1R signaling cascade pathway
Signal Transduction pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
Regulation of AMPK activity via LKB1 pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Mitochondrial biogenesis pathway
Membrane Trafficking pathway
Organelle biogenesis and maintenance pathway
|
||||||||||||||||||||||
| KEGG |
Circadian rhythm pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Hypertrophic cardiomyopathy (HCM) pathway
|
||||||||||||||||||||||
| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
|
||||||||||||||||||||||
| PID NCI |
Direct p53 effectors
|
||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.458152 | ||||||||||||||||||||||
| RefSeq | NM_031869 XM_006530201 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS19598 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||