InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Maf

Summary

InnateDB Gene

IDBG-194495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Maf

Gene Name

avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog

Synonyms

2810401A20Rik; A230108G15Rik; AW047063; c-maf

Species

Mus musculus

Ensembl Gene

ENSMUSG00000055435

Encoded Proteins

IDBP-194497

avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog

IDBP-263098

avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178573:
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:115682942-115707794

Strand

Reverse strand

Band

Transcripts

ENSMUST00000069009	ENSMUSP00000067704
ENSMUST00000109104	ENSMUSP00000104732

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	7 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001816	cytokine production
GO:0002088	lens development in camera-type eye
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010628	positive regulation of gene expression
GO:0032330	regulation of chondrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048839	inner ear development
GO:0070306	lens fiber cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000178573

View Gene Order

ENSBTAG00000044192

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

ap1_pathway

AP-1 transcription factor network

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.275549 Mm.416112 Mm.439772 Mm.453171

RefSeq

NM_001025577

OMIM

CCDS

CCDS40486

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas