Version 5.4
Mus musculus Gene: Hspb8
Summary
InnateDB Gene IDBG-194611.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hspb8
Gene Name heat shock protein 8
Synonyms AU018630; AW413033; Cryac; D5Ucla4; E2IG1; H11; H11K; HSP20-like; HSP22
Species Mus musculus
Ensembl Gene ENSMUSG00000041548
Encoded Proteins
IDBP-194613
heat shock protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152137:
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:116408491-116422864
Strand Reverse strand
Band F
Transcripts
ENSMUST00000036991 ENSMUSP00000037007
ENSMUST00000133335
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006950 response to stress
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000152137
View Gene Order
ENSBTAG00000001303
Not yet available
Cross-References
SwissProt Q9JK92
TrEMBL
UniProt Splice Variant
Entrez Gene 80888
UniGene Mm.21549
RefSeq NM_030704
OMIM
CCDS CCDS19600
HPRD
IMGT
MGI ID MGI:2135756
MGI Symbol Hspb8
EMBL AF250139 AF273453 AK005052 BC011219
GenPept AAF65563 AAG00233 AAH11219 BAB23778
RNA Seq Atlas 80888

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca