Version 5.4
Mus musculus Gene: Grin2b
Summary
InnateDB Gene IDBG-194672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grin2b
Gene Name glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms AW490526; GluN2B; Nmdar2b; NR2B
Species Mus musculus
Ensembl Gene ENSMUSG00000030209
Encoded Proteins
IDBP-194674
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
IDBP-257137
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
IDBP-789141
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
IDBP-789142
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
IDBP-789143
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:135713232-136173511
Strand Reverse strand
Band G1
Transcripts
ENSMUST00000053880 ENSMUSP00000062284
ENSMUST00000111905 ENSMUSP00000107536
ENSMUST00000152012
ENSMUST00000143943 ENSMUSP00000140710
ENSMUST00000125905 ENSMUSP00000139706
ENSMUST00000188999 ENSMUSP00000140452
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 78 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0016594 glycine binding
Biological Process
GO:0001662 behavioral fear response
GO:0001701 in utero embryonic development
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0006810 transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0007268 synaptic transmission
GO:0007423 sensory organ development
GO:0007612 learning
GO:0007613 memory
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042596 fear response
GO:0045471 response to ethanol
GO:0048167 regulation of synaptic plasticity
GO:0048266 behavioral response to pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0008021 synaptic vesicle
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000000219
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05010
Alzheimer's disease pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04720
Long-term potentiation pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3X9V4 Q8CG69
UniProt Splice Variant
Entrez Gene 14812
UniGene Mm.436649
RefSeq XM_006505572 XM_006505573 XM_006505574 XM_006505575 NM_008171
OMIM
CCDS CCDS20648
HPRD
IMGT
MGI ID MGI:95821
MGI Symbol Grin2b
EMBL AC124500 AC124590 AC132119 AC161364 AJ459261 CH466572
GenPept CAD30666 EDL10558
RNA Seq Atlas 14812

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca