Version 5.4
Mus musculus Gene: Suds3
Summary
InnateDB Gene IDBG-194701.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Suds3
Gene Name suppressor of defective silencing 3 homolog (S. cerevisiae)
Synonyms 2400003N08Rik; 2410008L21Rik; AU067672; mSds3
Species Mus musculus
Ensembl Gene ENSMUSG00000066900
Encoded Proteins
IDBP-194703
suppressor of defective silencing 3 homolog (S. cerevisiae)
IDBP-624224
suppressor of defective silencing 3 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111707:
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:117091682-117115993
Strand Reverse strand
Band F
Transcripts
ENSMUST00000086471 ENSMUSP00000083662
ENSMUST00000166397 ENSMUSP00000130535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0016575 histone deacetylation
GO:0021762 substantia nigra development
GO:0043065 positive regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016580 Sin3 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111707
View Gene Order
ENSBTAG00000019757
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_257106
HDACs deacetylate histones pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_213048
Epigenetic regulation of gene expression pathway
REACT_226022
Gene Expression pathway
REACT_207632
Chromatin organization pathway
REACT_248114
HDACs deacetylate histones pathway
REACT_214253
NoRC negatively regulates rRNA expression pathway
REACT_215001
Negative epigenetic regulation of rRNA expression pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BR65
TrEMBL
UniProt Splice Variant
Entrez Gene 71954
UniGene Mm.34456
RefSeq NM_001122666 NM_178622
OMIM
CCDS CCDS51631 CCDS39232
HPRD
IMGT
MGI ID MGI:1919204
MGI Symbol Suds3
EMBL AF469109 AK043652 AK045475 AK138947 AK150633 BC055764 BC062176
GenPept AAH55764 AAH62176 AAM22676 BAC31608 BAC32387 BAE23831 BAE29722
RNA Seq Atlas 71954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca