InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vapa

Summary

InnateDB Gene

IDBG-194936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vapa

Gene Name

vesicle-associated membrane protein, associated protein A

Synonyms

33kDa; VAP33

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024091

Encoded Proteins

IDBP-194938

vesicle-associated membrane protein, associated protein A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101558:
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:65580056-65613555

Strand

Reverse strand

Band

E1.1

Transcripts

ENSMUST00000024897

ENSMUSP00000024897

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007165	signal transduction
GO:0008219	cell death
GO:0031175	neuron projection development
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070972	protein localization to endoplasmic reticulum

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031982	vesicle
GO:0048471	perinuclear region of cytoplasm