InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pfn1

Summary

InnateDB Gene

IDBG-195117.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfn1

Gene Name

profilin 1

Synonyms

Pfn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018293

Encoded Proteins

IDBP-195119

profilin 1

IDBP-264302

profilin 1

IDBP-717801

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:70651850-70654644

Strand

Reverse strand

Band

Transcripts

ENSMUST00000018437	ENSMUSP00000018437
ENSMUST00000108549	ENSMUSP00000104189
ENSMUST00000177669
ENSMUST00000178254	ENSMUSP00000136219

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000774	adenyl-nucleotide exchange factor activity
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0017048	Rho GTPase binding
GO:0044822	poly(A) RNA binding
GO:0070064	proline-rich region binding

Biological Process

GO:0001843	neural tube closure
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008064	regulation of actin polymerization or depolymerization
GO:0010033	response to organic substance
GO:0010634	positive regulation of epithelial cell migration
GO:0030036	actin cytoskeleton organization
GO:0030837	negative regulation of actin filament polymerization
GO:0030838	positive regulation of actin filament polymerization
GO:0032232	negative regulation of actin filament bundle assembly
GO:0032781	positive regulation of ATPase activity
GO:0042989	sequestering of actin monomers
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription
GO:0051054	positive regulation of DNA metabolic process
GO:0051496	positive regulation of stress fiber assembly
GO:0051497	negative regulation of stress fiber assembly
GO:0071363	cellular response to growth factor stimulus
GO:1900029	positive regulation of ruffle assembly

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0043005	neuron projection
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle