InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stat6

Summary

InnateDB Gene

IDBG-195602.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat6

Gene Name

signal transducer and activator of transcription 6

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002147

Encoded Proteins

IDBP-195604

signal transducer and activator of transcription 6

IDBP-400352

signal transducer and activator of transcription 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22000020

Stat6 is phosphorylated upon viral infection and translocates to the nucleus to induce genes responsible for immune cell homing.

PMID 26953325

Stat6 signalling negatively regulates γδ17 T cells, which plays a front-line role in mucosal immunity.

InnateDB Annotation from Orthologs

Summary

PMID 17971840

[Homo sapiens] Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that mediates IL-13 cytokine signaling.

PMID 16433852

[Homo sapiens] STAT6 plays a role in the interleukin-4 (IL-4)-mediated modulation of TLR4 expression and the responsiveness of cells to lipopolysaccharide (LPS).

PMID 22000020

[Homo sapiens] STAT6 is phosphorylated upon viral infection and translocates to the nucleus to induce genes responsible for immune cell homing. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166888:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:127642986-127660957

Strand

Forward strand

Band

Transcripts

ENSMUST00000092074	ENSMUSP00000089708
ENSMUST00000120279	ENSMUSP00000112722
ENSMUST00000128072
ENSMUST00000156231
ENSMUST00000145470

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	18 [view]
Protein-DNA	17 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002296	T-helper 1 cell lineage commitment
GO:0002829	negative regulation of type 2 immune response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0033598	mammary gland epithelial cell proliferation
GO:0034097	response to cytokine
GO:0035771	interleukin-4-mediated signaling pathway
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0060443	mammary gland morphogenesis
GO:0070301	cellular response to hydrogen peroxide
GO:1902170	cellular response to reactive nitrogen species