Version 5.4
Mus musculus Gene: Sec11a
Summary
InnateDB Gene IDBG-195776.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec11a
Gene Name SEC11 homolog A (S. cerevisiae)
Synonyms 1810012E07Rik; 18kDa; Sec11l1; sid2895; Sid2895p; Spc18
Species Mus musculus
Ensembl Gene ENSMUSG00000025724
Encoded Proteins
IDBP-195778
SEC11 homolog A (S. cerevisiae)
IDBP-400501
SEC11 homolog A (S. cerevisiae)
IDBP-400499
SEC11 homolog A (S. cerevisiae)
IDBP-400498
SEC11 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140612:
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:80904889-80947780
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000026818 ENSMUSP00000026818
ENSMUST00000120285 ENSMUSP00000112944
ENSMUST00000117383 ENSMUSP00000113601
ENSMUST00000119980 ENSMUSP00000112425
ENSMUST00000147813
ENSMUST00000150049
ENSMUST00000130981
ENSMUST00000153053
ENSMUST00000147881
ENSMUST00000136556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0008150 biological_process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140612
View Gene Order
ENSBTAG00000011239
Not yet available
Pathways
NETPATH
REACTOME
REACT_230557
Incretin synthesis, secretion, and inactivation pathway
REACT_259776
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_196445
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_233293
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_233572
Gene Expression pathway
REACT_253751
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
KEGG
mmu03060
Protein export pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19189
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_23824
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
REACT_24019
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_71
Gene Expression pathway
REACT_210701
Peptide hormone metabolism pathway
REACT_221721
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_205221
Incretin synthesis, secretion, and inactivation pathway
REACT_206064
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_226022
Gene Expression pathway
REACT_223503
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_209048
Translation pathway
REACT_213782
Metabolism of proteins pathway
REACT_225796
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
KEGG
hsa03060
Protein export pathway
INOH
PID NCI
Cross-References
SwissProt Q9R0P6
TrEMBL Q6PET3
UniProt Splice Variant
Entrez Gene 56529
UniGene Mm.43760
RefSeq NM_019951
OMIM
CCDS CCDS21401
HPRD
IMGT
MGI ID MGI:1929464
MGI Symbol Sec11a
EMBL AB025405 AK007449 BC010484 BC057885
GenPept AAH10484 AAH57885 BAA84690 BAB25044
RNA Seq Atlas 56529

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca