Mus musculus Gene: Alas1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-195828.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Alas1 | ||||||||||||||||||||||
Gene Name | aminolevulinic acid synthase 1 | ||||||||||||||||||||||
Synonyms | ALAS; Alas-1; Alas-h; ALAS-N | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000032786 | ||||||||||||||||||||||
Encoded Proteins |
aminolevulinic acid synthase 1
aminolevulinic acid synthase 1
aminolevulinic acid synthase 1
aminolevulinic acid synthase 1
aminolevulinic acid synthase 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023330:
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:106233455-106248126 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | F1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Organelle biogenesis and maintenance pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Heme biosynthesis pathway
Transcriptional activation of mitochondrial biogenesis pathway
PPARA activates gene expression pathway
Metabolism of porphyrins pathway
Mitochondrial biogenesis pathway
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KEGG |
Glycine, serine and threonine metabolism pathway
Porphyrin and chlorophyll metabolism pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
PPARA activates gene expression pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Heme biosynthesis pathway
Organelle biogenesis and maintenance pathway
Metabolism of lipids and lipoproteins pathway
Mitochondrial biogenesis pathway
Metabolism of porphyrins pathway
Transcriptional activation of mitochondrial biogenesis pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Transcriptional activation of mitochondrial biogenesis pathway
Metabolism of porphyrins pathway
Heme biosynthesis pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
PPARA activates gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Mitochondrial biogenesis pathway
Organelle biogenesis and maintenance pathway
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KEGG |
Glycine, serine and threonine metabolism pathway
Porphyrin and chlorophyll metabolism pathway
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INOH |
Glycine Serine metabolism pathway
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PID NCI |
FOXA2 and FOXA3 transcription factor networks
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.290578 | ||||||||||||||||||||||
RefSeq | NM_001291835 NM_020559 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS40756 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||