InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Derl2

Summary

InnateDB Gene

IDBG-195837.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Derl2

Gene Name

Der1-like domain family, member 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018442

Encoded Proteins

IDBP-716838

IDBP-264349

Der1-like domain family, member 2

IDBP-536369

Der1-like domain family, member 2

IDBP-718508

IDBP-718268

IDBP-625180

Der1-like domain family, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072849:
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:71007164-71019841

Strand

Reverse strand

Band

Transcripts

ENSMUST00000018586	ENSMUSP00000136261
ENSMUST00000108523	ENSMUSP00000104163
ENSMUST00000143850	ENSMUSP00000117052
ENSMUST00000140712
ENSMUST00000132198	ENSMUSP00000136401
ENSMUST00000131340	ENSMUSP00000135984
ENSMUST00000171041	ENSMUSP00000127568

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0001967	suckling behavior
GO:0008284	positive regulation of cell proliferation
GO:0030307	positive regulation of cell growth
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0030970	retrograde protein transport, ER to cytosol

Cellular Component

GO:0005769	early endosome
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0030176	integral component of endoplasmic reticulum membrane