InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddx54

Summary

InnateDB Gene

IDBG-195958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx54

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

Synonyms

2410015A15Rik; AI414901; DP97

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029599

Encoded Proteins

IDBP-195960

DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123064:
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:120613130-120628590

Strand

Forward strand

Band

Transcripts

ENSMUST00000031598

ENSMUSP00000031598

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005102	receptor binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0030331	estrogen receptor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing
GO:0016070	RNA metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000123064

View Gene Order

ENSBTAG00000011930

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

erb_genomic_pathway

Validated nuclear estrogen receptor beta network

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

Cross-References

SwissProt

Q8K4L0

TrEMBL

Q6IQZ1 Q8VDG2

UniProt Splice Variant

Entrez Gene

71990

UniGene

RefSeq

NM_028041 XM_006530464

OMIM

CCDS

CCDS39241

HPRD

IMGT

MGI ID

MGI:1919240

MGI Symbol

Ddx54

EMBL

AF319547 BC021900 BC043699 BC071251

GenPept

AAH21900 AAH43699 AAH71251 AAM47540

RNA Seq Atlas

71990