Version 5.4
Mus musculus Gene: Usp10
Summary
InnateDB Gene IDBG-196026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp10
Gene Name ubiquitin specific peptidase 10
Synonyms 2610014N07Rik; mKIAA0190; UBPO; Uchrp
Species Mus musculus
Ensembl Gene ENSMUSG00000031826
Encoded Proteins
IDBP-263336
ubiquitin specific peptidase 10
IDBP-263338
ubiquitin specific peptidase 10
IDBP-541944
ubiquitin specific peptidase 10
IDBP-623157
ubiquitin specific peptidase 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103194:
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:119910360-119957560
Strand Forward strand
Band E1
Transcripts
ENSMUST00000108988 ENSMUSP00000104616
ENSMUST00000108982 ENSMUSP00000104610
ENSMUST00000144458 ENSMUSP00000123590
ENSMUST00000143615
ENSMUST00000135210
ENSMUST00000142432
ENSMUST00000125066
ENSMUST00000137310
ENSMUST00000148767
ENSMUST00000134729 ENSMUSP00000134182
ENSMUST00000139648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
GO:0044325 ion channel binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006914 autophagy
GO:0010506 regulation of autophagy
GO:0016579 protein deubiquitination
GO:0030330 DNA damage response, signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103194
View Gene Order
ENSBTAG00000009446
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.256910 Mm.409707
RefSeq NM_009462 XM_006530846 XM_006530847
OMIM
CCDS CCDS40495
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca