InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim63

Summary

InnateDB Gene

IDBG-196150.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim63

Gene Name

tripartite motif-containing 63

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028834

Encoded Proteins

IDBP-196152

tripartite motif-containing 63

IDBP-269943

tripartite motif-containing 63

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM63 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158022:
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:134315120-134329629

Strand

Forward strand

Band

Transcripts

ENSMUST00000030638	ENSMUSP00000030638
ENSMUST00000105875	ENSMUSP00000101501
ENSMUST00000134164
ENSMUST00000135576

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	83 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031432	titin binding
GO:0046872	metal ion binding

Biological Process

GO:0006936	muscle contraction
GO:0010468	regulation of gene expression
GO:0014732	skeletal muscle atrophy
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051384	response to glucocorticoid
GO:0070555	response to interleukin-1
GO:0071549	cellular response to dexamethasone stimulus

Cellular Component

GO:0005622	intracellular
GO:0043292	contractile fiber

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000158022

View Gene Order

ENSBTAG00000005085

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.331961 Mm.462292

RefSeq

NM_001039048

OMIM

CCDS

CCDS38914

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas