InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stmn1

Summary

InnateDB Gene

IDBG-196306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stmn1

Gene Name

stathmin 1

Synonyms

19k; Lag; Lap18; Op18; P18; P19; Pig; Pp17; Pp18; Pp19; Pr22; Smn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028832

Encoded Proteins

IDBP-196308

stathmin 1

IDBP-269958

stathmin 1

IDBP-269960

stathmin 1

IDBP-537152

stathmin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26082487

Stmn1 overexpression impacts microtubule stability, impairs cell spreading, reduces activation-associated phenotypes andreduces complement receptor 3 (CR3)-mediated phagocytosis and cellular activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117632:
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:134468320-134473843

Strand

Forward strand

Band

Transcripts

ENSMUST00000030636	ENSMUSP00000030636
ENSMUST00000105868	ENSMUSP00000101494
ENSMUST00000105867	ENSMUSP00000101493
ENSMUST00000130253
ENSMUST00000127279	ENSMUSP00000119547

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015631	tubulin binding

Biological Process

GO:0007019	microtubule depolymerization
GO:0007052	mitotic spindle organization
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0009615	response to virus
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0031115	negative regulation of microtubule polymerization
GO:0045087	innate immune response (InnateDB)
GO:0051272	positive regulation of cellular component movement

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117632

View Gene Order

ENSBTAG00000013761

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

p38gammadeltapathway

Signaling mediated by p38-gamma and p38-delta

aurora_b_pathway

Aurora B signaling

Cross-References

SwissProt

P54227

TrEMBL

D3Z1Z8 D3Z5N2 Q545B6

UniProt Splice Variant

Entrez Gene

16765

UniGene

RefSeq

NM_019641

OMIM

CCDS

CCDS18772

HPRD

IMGT

MGI ID

MGI:96739

MGI Symbol

Stmn1

EMBL

AK012231 AK012347 AL669982 BC010581 BC031831 BC054396 CH466552 L20256 L20257 L20258 X94915

GenPept

AAH10581 AAH31831 AAH54396 BAB28109 BAB28178 CAA64401 EDL30008 EDL30009

RNA Seq Atlas

16765