InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myl12b

Summary

InnateDB Gene

IDBG-196463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myl12b

Gene Name

myosin, light chain 12B, regulatory

Synonyms

1500001M02Rik; C77744; Mylc2b; RLC-B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034868

Encoded Proteins

IDBP-196465

myosin, light chain 12B, regulatory

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118680:
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:70973920-70990787

Strand

Reverse strand

Band

E1.3

Transcripts

ENSMUST00000038446	ENSMUSP00000042364
ENSMUST00000137537
ENSMUST00000131820

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0008360

regulation of cell shape

Cellular Component

GO:0001725	stress fiber
GO:0016460	myosin II complex
GO:0030018	Z disc
GO:0043234	protein complex
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome