InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grm2

Summary

InnateDB Gene

IDBG-196500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm2

Gene Name

glutamate receptor, metabotropic 2

Synonyms

4930441L02Rik; Gprc1b; mGluR2; mGluR7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023192

Encoded Proteins

IDBP-196502

glutamate receptor, metabotropic 2

IDBP-789407

glutamate receptor, metabotropic 2

IDBP-789408

glutamate receptor, metabotropic 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164082:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:106643095-106656082

Strand

Reverse strand

Band

Transcripts

ENSMUST00000023959	ENSMUSP00000023959
ENSMUST00000188527	ENSMUSP00000139729
ENSMUST00000189020	ENSMUSP00000140077
ENSMUST00000191330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001641	group II metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0014047	glutamate secretion
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005622	intracellular
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0043005	neuron projection