Mus musculus Gene: Manf | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-196820.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Manf | ||||||||||
Gene Name | mesencephalic astrocyte-derived neurotrophic factor | ||||||||||
Synonyms | 3230402M22Rik; AA407711; AA408789; AA673178; Armet; D17914; D18Mgi17 | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Gene | ENSMUSG00000032575 | ||||||||||
Encoded Proteins |
mesencephalic astrocyte-derived neurotrophic factor
mesencephalic astrocyte-derived neurotrophic factor
mesencephalic astrocyte-derived neurotrophic factor
mesencephalic astrocyte-derived neurotrophic factor
mesencephalic astrocyte-derived neurotrophic factor
mesencephalic astrocyte-derived neurotrophic factor
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145050:
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010] The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 9:106838312-106891979 | ||||||||||
Strand | Reverse strand | ||||||||||
Band | F1 | ||||||||||
Transcripts | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 74840 | ||||||||||
UniGene | Mm.29778 Mm.471819 | ||||||||||
RefSeq | NM_029103 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS23486 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
MGI ID | MGI:1922090 | ||||||||||
MGI Symbol | Manf | ||||||||||
EMBL | |||||||||||
GenPept | |||||||||||
RNA Seq Atlas | 74840 | ||||||||||