InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdc73

Summary

InnateDB Gene

IDBG-196894.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc73

Gene Name

cell division cycle 73, Paf1/RNA polymerase II complex component

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026361

Encoded Proteins

IDBP-196898

cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

IDBP-789678

cell division cycle 73, Paf1/RNA polymerase II complex component

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134371:
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:143598800-143702893

Strand

Reverse strand

Band

Transcripts

ENSMUST00000018337	ENSMUSP00000018337
ENSMUST00000162638
ENSMUST00000159794	ENSMUSP00000139872
ENSMUST00000188838
ENSMUST00000189597

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	89 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001711	endodermal cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006378	mRNA polyadenylation
GO:0007049	cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0010390	histone monoubiquitination
GO:0016055	Wnt signaling pathway
GO:0019827	stem cell maintenance
GO:0030177	positive regulation of Wnt signaling pathway
GO:0031442	positive regulation of mRNA 3'-end processing
GO:0031648	protein destabilization
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523	histone H2B ubiquitination
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048147	negative regulation of fibroblast proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0071222	cellular response to lipopolysaccharide
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle