InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndc80

Summary

InnateDB Gene

IDBG-196982.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndc80

Gene Name

NDC80 homolog, kinetochore complex component (S. cerevisiae)

Synonyms

2610020P18Rik; AV139730; HEC; HEC1; Kntc2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024056

Encoded Proteins

IDBP-196984

NDC80 homolog, kinetochore complex component (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080986:
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:71496100-71526857

Strand

Reverse strand

Band

E1.3

Transcripts

ENSMUST00000024851

ENSMUSP00000024851

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0007052	mitotic spindle organization
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0008608	attachment of spindle microtubules to kinetochore