InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnj8

Summary

InnateDB Gene

IDBG-196988.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnj8

Gene Name

potassium inwardly-rectifying channel, subfamily J, member 8

Synonyms

AI448900; gnite; Kir6.1; slmbr; sltr

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030247

Encoded Proteins

IDBP-196990

potassium inwardly-rectifying channel, subfamily J, member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21719711

Kcnj8 is an ATP-sensitive potassium channel that restricts cardiotropic RNA virus replication.

InnateDB Annotation from Orthologs

Summary

PMID 21719711

[Homo sapiens] KCNJ8 is an ATP-sensitive potassium channel that restricts cardiotropic RNA virus replication. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121361:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:142564939-142571356

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032374

ENSMUSP00000032374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015272	ATP-activated inward rectifier potassium channel activity
GO:0017098	sulfonylurea receptor binding

Biological Process

GO:0001822	kidney development
GO:0006813	potassium ion transport
GO:0007507	heart development
GO:0009268	response to pH
GO:0010107	potassium ion import
GO:0032496	response to lipopolysaccharide
GO:0034765	regulation of ion transmembrane transport
GO:0042311	vasodilation
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus

Cellular Component

GO:0005739	mitochondrion
GO:0008282	ATP-sensitive potassium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030016	myofibril
GO:0042383	sarcolemma
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000121361

View Gene Order

ENSBTAG00000002551

Not yet available

Pathways

NETPATH

REACTOME

REACT_214393

Inwardly rectifying K+ channels pathway

REACT_199102

ATP sensitive Potassium channels pathway

REACT_202800

Potassium Channels pathway

REACT_259290

Neuronal System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75775

ATP sensitive Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75918

Inwardly rectifying K+ channels pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P97794

TrEMBL

Q3U118

UniProt Splice Variant

Entrez Gene

16523

UniGene

RefSeq

NM_008428 XM_006506915

OMIM

CCDS

CCDS20685

HPRD

IMGT

MGI ID

MGI:1100508

MGI Symbol

Kcnj8

EMBL

AK156346 BC003756 CH466572 D88159

GenPept

AAH03756 BAA13550 BAE33682 EDL10646

RNA Seq Atlas

16523