Version 5.4
Mus musculus Gene: Glrx2
Summary
InnateDB Gene IDBG-196991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glrx2
Gene Name glutaredoxin 2 (thioltransferase)
Synonyms 1700010P22Rik; AI645710; Grx2
Species Mus musculus
Ensembl Gene ENSMUSG00000018196
Encoded Proteins
IDBP-196997
glutaredoxin 2 (thioltransferase)
IDBP-257019
glutaredoxin 2 (thioltransferase)
IDBP-534430
glutaredoxin 2 (thioltransferase)
IDBP-532619
glutaredoxin 2 (thioltransferase)
IDBP-542467
glutaredoxin 2 (thioltransferase)
IDBP-788123
glutaredoxin 2 (thioltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023572:
The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:143716338-143749676
Strand Forward strand
Band F
Transcripts
ENSMUST00000050491 ENSMUSP00000053443
ENSMUST00000111957 ENSMUSP00000107588
ENSMUST00000145969 ENSMUSP00000121665
ENSMUST00000126514
ENSMUST00000148600
ENSMUST00000149103
ENSMUST00000145571 ENSMUSP00000115893
ENSMUST00000129653 ENSMUSP00000121010
ENSMUST00000152435
ENSMUST00000185367
ENSMUST00000185362 ENSMUSP00000141022
ENSMUST00000190211
ENSMUST00000188783
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0010033 response to organic substance
GO:0042542 response to hydrogen peroxide
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000023572
View Gene Order
ENSBTAG00000015972
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272727 Mm.454828
RefSeq NM_001038592 NM_001038593 NM_001038594 NM_023505
OMIM
CCDS CCDS15343 CCDS15344
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca