Version 5.4
Homo sapiens Gene: GGT2
Summary
InnateDB Gene IDBG-1970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGT2
Gene Name gamma-glutamyltransferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133475
Encoded Proteins
IDBP-292655
gamma-glutamyltransferase 2
IDBP-292657
gamma-glutamyltransferase 2
IDBP-364772
gamma-glutamyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:21207973-21227637
Strand Reverse strand
Band q11.21
Transcripts
ENST00000401924 ENSP00000385721
ENST00000405188 ENSP00000385601
ENST00000424627 ENSP00000402035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006805 xenobiotic metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0044281 small molecule metabolic process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0031362 anchored component of external side of plasma membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P36268
TrEMBL C9JGF3 C9JIY6
UniProt Splice Variant
Entrez Gene 728441
UniGene Hs.568255 Hs.595809
RefSeq
HUGO HGNC:4251
OMIM 137181
CCDS
HPRD
IMGT
EMBL AA632626 AP000356 AP000550 BG743316 M30474 M30475 M30476 M30477 M30478 M30479
GenPept AAA52548 AAA52765
RNA Seq Atlas 102724197 728441

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca