Version 5.4
Mus musculus Gene: Pla2g4a
Summary
InnateDB Gene IDBG-197265.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g4a
Gene Name phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms cPLA2; cPLA2alpha; Pla2g4
Species Mus musculus
Ensembl Gene ENSMUSG00000056220
Encoded Proteins
IDBP-197267
phospholipase A2, group IVA (cytosolic, calcium-dependent)
IDBP-257083
phospholipase A2, group IVA (cytosolic, calcium-dependent)
IDBP-789690
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22003202
Pla2g4a and its metabolite lipid mediators induce autophagy in macrophages and monocytes. This autophagy is Atg5 dependent and independent of changes in mTOR or autophagic flux.
InnateDB Annotation from Orthologs
Summary
PMID 22003202
[Homo sapiens] PLA2G4A and its metabolite lipid mediators induce autophagy in macrophages and monocytes. This autophagy is ATG5 dependent and independent of changes in mTOR or autophagic flux. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116711:
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:149829618-149961290
Strand Reverse strand
Band G1
Transcripts
ENSMUST00000070200 ENSMUSP00000070868
ENSMUST00000111926 ENSMUSP00000107557
ENSMUST00000155438
ENSMUST00000142040
ENSMUST00000134676
ENSMUST00000190507 ENSMUSP00000139851
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0042127 regulation of cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0046456 icosanoid biosynthetic process
GO:0050482 arachidonic acid secretion
GO:0071236 cellular response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116711
View Gene Order
ENSBTAG00000013298
Not yet available
Pathways
NETPATH
REACTOME
REACT_199038
Acyl chain remodelling of PC pathway
REACT_199039
Acyl chain remodelling of PG pathway
REACT_199030
Acyl chain remodelling of PS pathway
REACT_199034
Acyl chain remodeling of CL pathway
REACT_208483
Platelet homeostasis pathway
REACT_224553
Hemostasis pathway
REACT_254215
Signaling by GPCR pathway
REACT_199022
Hydrolysis of LPC pathway
REACT_199027
Acyl chain remodelling of PE pathway
REACT_199024
Acyl chain remodelling of PI pathway
REACT_259326
Ca-dependent events pathway
REACT_217633
phospho-PLA2 pathway pathway
REACT_188937
Metabolism pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_250548
Platelet sensitization by LDL pathway
REACT_259068
ADP signalling through P2Y purinoceptor 1 pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188640
Synthesis of PA pathway
REACT_188643
Phospholipid metabolism pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
REACT_253342
PLC beta mediated events pathway
REACT_251507
Signal amplification pathway
REACT_248370
G-protein mediated events pathway
REACT_188625
Arachidonic acid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu04370
VEGF signaling pathway pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu00591
Linoleic acid metabolism pathway
mmu04010
MAPK signaling pathway pathway
mmu00592
alpha-Linolenic acid metabolism pathway
mmu04730
Long-term depression pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_13
IL1 pathway
NetPath_17
IL5 pathway
REACTOME
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_15466
phospho-PLA2 pathway pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_120829
Acyl chain remodelling of PC pathway
REACT_120722
Acyl chain remodelling of PI pathway
REACT_120977
Hydrolysis of LPC pathway
REACT_121384
Acyl chain remodelling of PS pathway
REACT_120906
Synthesis of PA pathway
REACT_121324
Acyl chain remodelling of PG pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_121006
Acyl chain remodeling of CL pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_15526
G-protein mediated events pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_20524
Signal amplification pathway
REACT_15307
Ca-dependent events pathway
REACT_604
Hemostasis pathway
REACT_203916
Arachidonic acid metabolism pathway
REACT_211382
Synthesis of PA pathway
REACT_214993
Platelet sensitization by LDL pathway
REACT_205553
Acyl chain remodelling of PC pathway
REACT_205369
Signaling by GPCR pathway
REACT_202421
Glycerophospholipid biosynthesis pathway
REACT_226164
Acyl chain remodeling of CL pathway
REACT_206203
Acyl chain remodelling of PI pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_214353
Signal Transduction pathway
REACT_222735
Signal amplification pathway
REACT_211557
G-protein mediated events pathway
REACT_209440
Platelet homeostasis pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_227313
Hydrolysis of LPC pathway
REACT_211545
ADP signalling through P2Y purinoceptor 1 pathway
REACT_213422
PLC beta mediated events pathway
REACT_219139
Metabolism pathway
REACT_203126
phospho-PLA2 pathway pathway
REACT_224920
Acyl chain remodelling of PS pathway
REACT_218329
Phospholipid metabolism pathway
REACT_219672
Opioid Signalling pathway
REACT_223374
Ca-dependent events pathway
REACT_204784
Acyl chain remodelling of PE pathway
REACT_207095
Acyl chain remodelling of PG pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa04912
GnRH signaling pathway pathway
hsa00590
Arachidonic acid metabolism pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa04730
Long-term depression pathway
hsa00565
Ether lipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
endothelinpathway
Endothelins
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt P47713
TrEMBL Q3UMQ1
UniProt Splice Variant
Entrez Gene 18783
UniGene Mm.412912 Mm.4186
RefSeq NM_008869 XM_006529252
OMIM
CCDS CCDS15352
HPRD
IMGT
MGI ID MGI:1195256
MGI Symbol Pla2g4a
EMBL AK144750 BC003816 CH466520 M72394
GenPept AAB00796 AAH03816 BAE26047 EDL39489
RNA Seq Atlas 18783

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca