Version 5.4
Mus musculus Gene: Fah
Summary
InnateDB Gene IDBG-197375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fah
Gene Name fumarylacetoacetate hydrolase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030630
Encoded Proteins
IDBP-197377
fumarylacetoacetate hydrolase
IDBP-533812
fumarylacetoacetate hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103876:
This gene encodes the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:84585159-84606722
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000032865 ENSMUSP00000032865
ENSMUST00000128460 ENSMUSP00000121439
ENSMUST00000153126
ENSMUST00000134390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004334 fumarylacetoacetase activity
GO:0046872 metal ion binding
Biological Process
GO:0006527 arginine catabolic process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0008152 metabolic process
GO:0009072 aromatic amino acid family metabolic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103876
View Gene Order
ENSBTAG00000012338
Not yet available
Pathways
NETPATH
REACTOME
REACT_261966
Phenylalanine and tyrosine catabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
KEGG
mmu00350
Tyrosine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1786
Phenylalanine and tyrosine catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00350
Tyrosine metabolism pathway
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt P35505
TrEMBL D3Z2R9
UniProt Splice Variant
Entrez Gene 14085
UniGene Mm.3798
RefSeq NM_010176
OMIM
CCDS CCDS21418
HPRD
IMGT
MGI ID MGI:95482
MGI Symbol Fah
EMBL AC129605 AC132619 AK143759 AK158808 BC010767 M84145 Z11774
GenPept AAA37591 AAH10767 BAE25527 BAE34676 CAA77819
RNA Seq Atlas 14085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca