Version 5.4
Mus musculus Gene: Fuca1
Summary
InnateDB Gene IDBG-197387.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fuca1
Gene Name fucosidase, alpha-L- 1, tissue
Synonyms 0610006A03Rik; 9530055J05Rik; Afuc; Fuca
Species Mus musculus
Ensembl Gene ENSMUSG00000028673
Encoded Proteins
IDBP-197389
fucosidase, alpha-L- 1, tissue
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179163:
The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:135920735-135940311
Strand Forward strand
Band D3
Transcripts
ENSMUST00000030434 ENSMUSP00000030434
ENSMUST00000153592
ENSMUST00000142033
ENSMUST00000146290
ENSMUST00000142111
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004560 alpha-L-fucosidase activity
GO:0015928 fucosidase activity
GO:0030246 carbohydrate binding
GO:0042806 fucose binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006004 fucose metabolic process
GO:0016139 glycoside catabolic process
Cellular Component
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000179163
View Gene Order
ENSBTAG00000030434
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00511
Other glycan degradation pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00511
Other glycan degradation pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.439940 Mm.467404
RefSeq NM_024243
OMIM
CCDS CCDS18794
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca