Version 5.4
Mus musculus Gene: Itgae
Summary
InnateDB Gene IDBG-197618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgae
Gene Name integrin alpha E, epithelial-associated
Synonyms A530055J10; alpha-E1; alpha-M290; aM290; CD103
Species Mus musculus
Ensembl Gene ENSMUSG00000005947
Encoded Proteins
IDBP-197620
integrin alpha E, epithelial-associated
IDBP-197622
integrin alpha E, epithelial-associated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000083457:
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:73090583-73147446
Strand Forward strand
Band B4
Transcripts
ENSMUST00000006101 ENSMUSP00000006101
ENSMUST00000102537 ENSMUSP00000099596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
Cellular Component
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000083457
View Gene Order
ENSBTAG00000015264
Not yet available
Pathways
NETPATH
REACTOME
REACT_206066
Extracellular matrix organization pathway
REACT_216309
Integrin cell surface interactions pathway
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
integrin_cs_pathway
Integrin family cell surface interactions
integrin7_pathway
AlphaE beta7 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.96
RefSeq NM_008399 NM_172944
OMIM
CCDS CCDS24995 CCDS24996
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca