Mus musculus Gene: Sh2b3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-197739.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Sh2b3 | ||||||||||||||||||||||
Gene Name | SH2B adaptor protein 3 | ||||||||||||||||||||||
Synonyms | AI429800; Lnk | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000042594 | ||||||||||||||||||||||
Encoded Proteins |
SH2B adaptor protein 3
SH2B adaptor protein 3
SH2B adaptor protein 3
SH2B adaptor protein 3
SH2B adaptor protein 3
SH2B adaptor protein 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111252:
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq, May 2010] This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:121815488-121836859 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | F | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Hemostasis pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Factors involved in megakaryocyte development and platelet production pathway
Signal Transduction pathway
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KEGG |
Neurotrophin signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
KitReceptor pathway
TCR pathway
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REACTOME |
Factors involved in megakaryocyte development and platelet production pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Signal Transduction pathway
Hemostasis pathway
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KEGG |
Neurotrophin signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI |
EPO signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | D3Z0T9 D6RCY9 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 16923 | ||||||||||||||||||||||
UniGene | Mm.437534 Mm.470237 Mm.65493 | ||||||||||||||||||||||
RefSeq | NM_008507 XM_006530169 XM_006530170 XM_006530171 XM_006530172 XM_006530173 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19641 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:893598 | ||||||||||||||||||||||
MGI Symbol | Sh2b3 | ||||||||||||||||||||||
EMBL | AC113302 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 16923 | ||||||||||||||||||||||