Version 5.4
Mus musculus Gene: Sema3b
Summary
InnateDB Gene IDBG-197927.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sema3b
Gene Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms SemA; sema5; Semaa; semaV
Species Mus musculus
Ensembl Gene ENSMUSG00000057969
Encoded Proteins
IDBP-197929
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
IDBP-197931
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
IDBP-197935
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
IDBP-197937
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
IDBP-197939
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
IDBP-741902
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted protein that belongs to the class 3 semaphorin/collapsin family. Members of this family play a role in growth cone guidance during neurogenesis. The encoded protein inhibits axonal extension. This protein is thought to be an osteoblast protein that regulates bone mass and affects skeletal homeostasis. A similar gene in humans functions as a tumor suppressor gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:107597674-107609229
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000073448 ENSMUSP00000073152
ENSMUST00000102532 ENSMUSP00000099591
ENSMUST00000102531 ENSMUSP00000099590
ENSMUST00000102530 ENSMUSP00000099589
ENSMUST00000102529 ENSMUSP00000099588
ENSMUST00000123926 ENSMUSP00000137952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4083 Mm.414311
RefSeq NM_001042779 NM_001291537 NM_001291538 NM_001291539 NM_009153 XM_006511662 XM_006511663 XM_006511664 XM_006511665 XM_006511666 XM_006511668 XM_006511669 XM_006511670 XM_006511671 XM_006511672 XM_006511673
OMIM
CCDS CCDS23501
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca