Version 5.4
Mus musculus Gene: Hvcn1
Summary
InnateDB Gene IDBG-197993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hvcn1
Gene Name hydrogen voltage-gated channel 1
Synonyms 0610039P13Rik; AI450555; BTS; HV1; mVSOP; Vsop.
Species Mus musculus
Ensembl Gene ENSMUSG00000064267
Encoded Proteins
IDBP-197995
hydrogen voltage-gated channel 1
IDBP-197997
hydrogen voltage-gated channel 1
IDBP-537431
hydrogen voltage-gated channel 1
IDBP-536732
hydrogen voltage-gated channel 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122986:
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:122206804-122242297
Strand Forward strand
Band F
Transcripts
ENSMUST00000072602 ENSMUSP00000072401
ENSMUST00000100747 ENSMUSP00000098312
ENSMUST00000145854 ENSMUSP00000118151
ENSMUST00000143560 ENSMUSP00000118013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0030171 voltage-gated proton channel activity
Biological Process
GO:0006811 ion transport
GO:0009268 response to pH
GO:0010043 response to zinc ion
GO:0015992 proton transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071294 cellular response to zinc ion
GO:0071467 cellular response to pH
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122986
View Gene Order
ENSBTAG00000009216
Not yet available
Pathways
NETPATH
REACTOME
REACT_196630
Sperm Motility And Taxes pathway
REACT_199082
Fertilization pathway
REACT_199085
Reproduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_163914
Fertilization pathway
REACT_163875
Sperm Motility And Taxes pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28804 Mm.437562
RefSeq NM_001042489 NM_028752 XM_006530471 XM_006530472 XM_006530473
OMIM
CCDS CCDS19644
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca