InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnf2

Summary

InnateDB Gene

IDBG-198115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf2

Gene Name

ring finger protein 2

Synonyms

AI326319; AI450156; AU019207; dinG; Ring1B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026484

Encoded Proteins

IDBP-198117

ring finger protein 2

IDBP-789223

ring finger protein 2

IDBP-789224

ring finger protein 2

IDBP-789225

ring finger protein 2

IDBP-789226

ring finger protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121481:
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:151458004-151500955

Strand

Reverse strand

Band

Transcripts

ENSMUST00000076110	ENSMUSP00000075476
ENSMUST00000190070	ENSMUSP00000139676
ENSMUST00000187048	ENSMUSP00000140896
ENSMUST00000186415	ENSMUSP00000140594
ENSMUST00000188871
ENSMUST00000185945
ENSMUST00000187991	ENSMUSP00000140299

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	154 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0071535	RING-like zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0001702	gastrulation with mouth forming second
GO:0006351	transcription, DNA-templated
GO:0009948	anterior/posterior axis specification
GO:0016574	histone ubiquitination
GO:0035518	histone H2A monoubiquitination
GO:0036353	histone H2A-K119 monoubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000791	euchromatin
GO:0000792	heterochromatin
GO:0001739	sex chromatin
GO:0005634	nucleus
GO:0016604	nuclear body
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex
GO:0071339	MLL1 complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000121481

View Gene Order

ENSBTAG00000000023

Not yet available

Pathways

NETPATH

REACTOME

REACT_188970

Oxidative Stress Induced Senescence pathway

REACT_188957

Cellular responses to stress pathway

REACT_188820

Cellular Senescence pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169274

Cellular Senescence pathway

REACT_169436

Oxidative Stress Induced Senescence pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_011277 XM_006529269

OMIM

CCDS

CCDS15362

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas