Version 5.4
| Mus musculus Gene: Cdk2 | |||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||
| InnateDB Gene | IDBG-198142.6 | ||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
| Gene Symbol | Cdk2 | ||||||||||||||||||||||||
| Gene Name | cyclin-dependent kinase 2 | ||||||||||||||||||||||||
| Synonyms | A630093N05Rik | ||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000025358 | ||||||||||||||||||||||||
| Encoded Proteins |
cyclin-dependent kinase 2
cyclin-dependent kinase 2
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123374:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008] This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
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| Gene Information | |||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||
| Genomic Location | Chromosome 10:128697939-128705051 | ||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||
| Band | D3 | ||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 529 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||
| REACTOME |
Meiotic Recombination pathway
G2/M Transition pathway
Mus musculus biological processes pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
Hemostasis pathway
G2 Phase pathway
DNA Replication pathway
Switching of origins to a post-replicative state pathway
Cellular responses to stress pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
DNA Damage/Telomere Stress Induced Senescence pathway
p53-Dependent G1 DNA Damage Response pathway
p53-Dependent G1/S DNA damage checkpoint pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Cell Cycle Checkpoints pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Regulation of DNA replication pathway
Cellular Senescence pathway
Activation of the pre-replicative complex pathway
Factors involved in megakaryocyte development and platelet production pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
Mitotic G2-G2/M phases pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Regulation of mitotic cell cycle pathway
G1/S DNA Damage Checkpoints pathway
Cyclin A/B1 associated events during G2/M transition pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
Cyclin E associated events during G1/S transition pathway
Meiosis pathway
Meiotic recombination pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
DNA Replication Pre-Initiation pathway
S Phase pathway
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| KEGG |
p53 signaling pathway pathway
Cell cycle pathway
Small cell lung cancer pathway
Prostate cancer pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
ID pathway
KitReceptor pathway
TGF_beta_Receptor pathway
BCR pathway
IL2 pathway
TSH pathway
Oncostatin_M pathway
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| REACTOME |
Activation of ATR in response to replication stress pathway
p53-Dependent G1 DNA Damage Response pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Activation of the pre-replicative complex pathway
G0 and Early G1 pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Cyclin E associated events during G1/S transition pathway
G2 Phase pathway
Cyclin A/B1 associated events during G2/M transition pathway
Factors involved in megakaryocyte development and platelet production pathway
Meiotic recombination pathway
DNA Replication pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Cellular responses to stress pathway
Synthesis of DNA pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
G2/M Transition pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
G1/S DNA Damage Checkpoints pathway
Mitotic G2-G2/M phases pathway
Meiosis pathway
Regulation of DNA replication pathway
Hemostasis pathway
Cell Cycle Checkpoints pathway
G2/M Transition pathway
G0 and Early G1 pathway
S Phase pathway
G2 Phase pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Mitotic G1-G1/S phases pathway
Cyclin A/B1 associated events during G2/M transition pathway
DNA Replication Pre-Initiation pathway
Factors involved in megakaryocyte development and platelet production pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
DNA Replication pathway
G1/S DNA Damage Checkpoints pathway
G1/S Transition pathway
Regulation of DNA replication pathway
Orc1 removal from chromatin pathway
Cellular responses to stress pathway
Meiosis pathway
Hemostasis pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Synthesis of DNA pathway
Cell Cycle pathway
Cellular Senescence pathway
Cyclin E associated events during G1/S transition pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Regulation of mitotic cell cycle pathway
M/G1 Transition pathway
p53-Dependent G1 DNA Damage Response pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
APC/C-mediated degradation of cell cycle proteins pathway
Meiotic recombination pathway
G2/M Checkpoints pathway
Activation of the pre-replicative complex pathway
Activation of ATR in response to replication stress pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Switching of origins to a post-replicative state pathway
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| KEGG |
Cell cycle pathway
Small cell lung cancer pathway
Prostate cancer pathway
p53 signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Oocyte meiosis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI |
Regulation of retinoblastoma protein
IL2-mediated signaling events
mTOR signaling pathway
FoxO family signaling
p53 pathway
p73 transcription factor network
E2F transcription factor network
Signaling events mediated by PRL
BARD1 signaling events
ATR signaling pathway
FOXM1 transcription factor network
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| Cross-References | |||||||||||||||||||||||||
| SwissProt | P97377 | ||||||||||||||||||||||||
| TrEMBL | Q3U6X7 | ||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||
| Entrez Gene | 12566 | ||||||||||||||||||||||||
| UniGene | Mm.471425 | ||||||||||||||||||||||||
| RefSeq | NM_016756 NM_183417 XM_006513162 | ||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||
| CCDS | CCDS24288 CCDS24289 | ||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||
| MGI ID | MGI:104772 | ||||||||||||||||||||||||
| MGI Symbol | Cdk2 | ||||||||||||||||||||||||
| EMBL | AJ223732 AJ223733 AK152922 BC005654 CH466578 U63337 | ||||||||||||||||||||||||
| GenPept | AAB37128 AAH05654 BAE31597 CAA11533 CAA11534 CAA11535 EDL24600 | ||||||||||||||||||||||||
| RNA Seq Atlas | 12566 | ||||||||||||||||||||||||