InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ephb2

Summary

InnateDB Gene

IDBG-198182.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephb2

Gene Name

Eph receptor B2

Synonyms

Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5; Qek5; Sek3; Tyro5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028664

Encoded Proteins

IDBP-198184

Eph receptor B2

IDBP-270003

Eph receptor B2

IDBP-270005

Eph receptor B2

IDBP-533422

Eph receptor B2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133216:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:136647539-136835988

Strand

Reverse strand

Band

Transcripts

ENSMUST00000059287	ENSMUSP00000058135
ENSMUST00000105846	ENSMUSP00000101472
ENSMUST00000105845	ENSMUSP00000101471
ENSMUST00000151502
ENSMUST00000156558	ENSMUSP00000116350
ENSMUST00000144573

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000902	cell morphogenesis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0007612	learning
GO:0009887	organ morphogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021631	optic nerve morphogenesis
GO:0021952	central nervous system projection neuron axonogenesis
GO:0031290	retinal ganglion cell axon guidance
GO:0048013	ephrin receptor signaling pathway
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0048593	camera-type eye morphogenesis
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis