Version 5.4
Mus musculus Gene: Spg7
Summary
InnateDB Gene IDBG-198199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spg7
Gene Name spastic paraplegia 7 homolog (human)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000000738
Encoded Proteins
IDBP-263609
spastic paraplegia 7 homolog (human)
IDBP-540842
spastic paraplegia 7 homolog (human)
IDBP-537840
spastic paraplegia 7 homolog (human)
IDBP-542294
spastic paraplegia 7 homolog (human)
IDBP-534301
spastic paraplegia 7 homolog (human)
IDBP-623772
spastic paraplegia 7 homolog (human)
IDBP-535122
spastic paraplegia 7 homolog (human)
IDBP-535422
spastic paraplegia 7 homolog (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197912:
This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 7. [provided by RefSeq, Jul 2008]
This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:123062942-123097760
Strand Forward strand
Band E1
Transcripts
ENSMUST00000108868 ENSMUSP00000104496
ENSMUST00000142541 ENSMUSP00000119017
ENSMUST00000125975 ENSMUSP00000120361
ENSMUST00000149248 ENSMUSP00000119552
ENSMUST00000153285 ENSMUSP00000115039
ENSMUST00000128803
ENSMUST00000153492 ENSMUSP00000133602
ENSMUST00000142150
ENSMUST00000128234 ENSMUSP00000120793
ENSMUST00000130787
ENSMUST00000152972
ENSMUST00000135991 ENSMUSP00000118066
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006508 proteolysis
GO:0007005 mitochondrion organization
GO:0007155 cell adhesion
GO:0008089 anterograde axon cargo transport
GO:0030155 regulation of cell adhesion
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197912
View Gene Order
ENSBTAG00000012041
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.292075 Mm.408845
RefSeq NM_153176
OMIM
CCDS CCDS40508
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca