Version 5.4
Mus musculus Gene: Mmp19
Summary
InnateDB Gene IDBG-198404.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mmp19
Gene Name matrix metallopeptidase 19
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025355
Encoded Proteins
IDBP-198406
matrix metallopeptidase 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123342:
This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128790953-128800824
Strand Forward strand
Band D3
Transcripts
ENSMUST00000026411 ENSMUSP00000026411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001542 ovulation from ovarian follicle
GO:0001554 luteolysis
GO:0006508 proteolysis
GO:0009725 response to hormone
GO:0030154 cell differentiation
GO:0030574 collagen catabolic process
GO:0051591 response to cAMP
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
GO:0031012 extracellular matrix
GO:0031225 anchored component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123342
View Gene Order
ENSBTAG00000009051
Not yet available
Pathways
NETPATH
REACTOME
REACT_206066
Extracellular matrix organization pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9JHI0
TrEMBL Q2KHP2 Q3UW97
UniProt Splice Variant
Entrez Gene 58223
UniGene Mm.131266
RefSeq NM_001164197 NM_021412
OMIM
CCDS CCDS24292
HPRD
IMGT
MGI ID MGI:1927899
MGI Symbol Mmp19
EMBL AF153199 AF155221 AF162446 AK086808 AK136517 BC112966 CH466578
GenPept AAF73292 AAF80464 AAG29880 AAI12967 BAC39747 BAE23019 EDL24613
RNA Seq Atlas 58223

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca