InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dhx9

Summary

InnateDB Gene

IDBG-199045.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhx9

Gene Name

DEAH (Asp-Glu-Ala-His) box polypeptide 9

Synonyms

AI326842; Ddx9; HEL-5; mHEL-5; NDHII; RHA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042699

Encoded Proteins

IDBP-199047

DEAH (Asp-Glu-Ala-His) box polypeptide 9

IDBP-787691

DEAH (Asp-Glu-Ala-His) box polypeptide 9

IDBP-787692

DEAH (Asp-Glu-Ala-His) box polypeptide 9

IDBP-787694

DEAH (Asp-Glu-Ala-His) box polypeptide 9

IDBP-787695

DEAH (Asp-Glu-Ala-His) box polypeptide 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20696886

[Homo sapiens] DHX9 interacts with CpG-B and was associated with TNF-alpha and IL-6 production and NF-kappaB activation upon CpG-B stimulation. DHX9 is localized in the cytosol and is found to bind to TLR domain of MYD88.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135829:
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:153455758-153487660

Strand

Reverse strand

Band

Transcripts

ENSMUST00000042141	ENSMUSP00000038135
ENSMUST00000186380	ENSMUSP00000139825
ENSMUST00000186966	ENSMUSP00000139806
ENSMUST00000190544	ENSMUSP00000140764
ENSMUST00000188345	ENSMUSP00000139827
ENSMUST00000189516
ENSMUST00000189509
ENSMUST00000190383
ENSMUST00000189425

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 151 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	151 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006200	ATP catabolic process
GO:0007623	circadian rhythm
GO:0034605	cellular response to heat
GO:0070934	CRD-mediated mRNA stabilization

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005813	centrosome
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0070937	CRD-mediated mRNA stability complex