InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnasel

Summary

InnateDB Gene

IDBG-199298.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnasel

Gene Name

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Synonyms

E230029I04Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000066800

Encoded Proteins

IDBP-199300

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

IDBP-788670

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

IDBP-788673

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

IDBP-788677

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21190483

Rnasel cleaves RNA during viral infections and the cleavage products induces the RIG-I pathway and production of Ifnb gene. In addition, Rnasel is implicated in the protection of central nervous system against viral-induced demyelination. A broader role in innate immunity is suggested by involvement of Rnasel in cytokine induction and endosomal pathways that suppress bacterial infections.

PMID 24324683

RNASEL contributes to innate immunity through regulating macrophage functions.

InnateDB Annotation from Orthologs

Summary

PMID 19075243

[Homo sapiens] RNASEL, antiviral endoribonuclease, is the terminal component of an RNA decay pathway that is an important mediator of IFN-induced antiviral activity and is required for the optimal induction of pro-inflammatory cytokines that play essential roles in host defence from bacterial pathogens.

PMID 19075243

[Homo sapiens] RNASEL regulates the expression of the endolysosomal protease, cathepsin-E, and endosome-associated activities, that function to eliminate internalized bacteria and may contribute to RNASEL antimicrobial action.

PMID 20833746

[Homo sapiens] RNASEL-mediated cleavage of Hepatitis C virus (HCV) RNA generates suppressor of virus RNA (svRNA) that activates DDX58 (RIG-I), thus propagating innate immune signalling to the interferon (IFN)-beta gene.

PMID 21190483

[Homo sapiens] RNASEL cleaves RNA during viral infections and the cleavage products induces the RIG-I pathway and production of IFNB gene. In addition, RNASEL is implicated in the protection of central nervous system against viral-induced demyelination. A broader role in innate immunity is suggested by involvement of RNASEL in cytokine induction and endosomal pathways that suppress bacterial infections.

PMID 25816776

[Homo sapiens] RNA cleavage products, catalyzed by RNASEL, bind to DHX33 to facilitate the formation of a complex with MAVS and NLRP3 during viral infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135828:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:153749426-153764221

Strand

Forward strand

Band

Transcripts

ENSMUST00000086209	ENSMUSP00000083385
ENSMUST00000182722	ENSMUSP00000138247
ENSMUST00000183241	ENSMUSP00000138752
ENSMUST00000182131
ENSMUST00000182538	ENSMUSP00000138734
ENSMUST00000182016

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0004540	ribonuclease activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019843	rRNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006364	rRNA processing
GO:0006397	mRNA processing
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0090501	RNA phosphodiester bond hydrolysis

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016363	nuclear matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000135828

View Gene Order

ENSBTAG00000009091

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05160

Hepatitis C pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

hsa05160

Hepatitis C pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.259254

RefSeq

NM_011882 XM_006529525 XM_006529526 XM_006529527 XM_006529528 XM_006529529 XM_006529530

OMIM

CCDS

CCDS15377

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas